How long does it take for CIN2 to evolve to CIN3 This statement is unfounded and not all CIN2 patients will evolve to CIN3. CIN is the English abbreviation for cervical intraepithelial neoplasia, generally can be divided into 3 grades, such as the patient’s grade for CIN2, this time we need to carry out P16 immunohistochemical staining of the patient for shunt, P16 staining is negative can be treated according to the low-grade cervical intraepithelial lesions, continue to follow up can be, most of the patients can naturally regress, will not evolve into CIN3. If CIN2 patients with P16 immunohistochemical staining for shunt are positive, there is a risk of evolving into CIN3 or even invasive carcinoma, then they need to be treated according to high-grade cervical intraepithelial lesions and should be treated with surgery in time. When the test results of patients are abnormal, they should be treated as early as possible under the guidance of professional physicians, so as to avoid delaying the condition and leading to adverse consequences.