The difference between lumbar spine lesion and lumbar disc herniation is that lumbar spine lesion includes lumbar disc herniation, and lumbar spine lesion covers a larger scope than lumbar disc herniation. Lumbar spine lesion generally refers to lumbar spine diseases caused by lumbar spine inflammation or tumor, such as lumbar spine tuberculosis caused by Mycobacterium tuberculosis invasion of lumbar spine, ankylosing spondylitis caused by HLA27, lumbar spinal stenosis caused by degenerative changes of vertebral canal, lumbar scoliosis caused by osteoporosis, and lumbar intervertebral disc protrusion caused by degenerative changes of lumbar intervertebral discs, and so on. Lumbar disc herniation is a type of lumbar spine lesion, which is mainly caused by degeneration of the intervertebral discs causing rupture of the annulus fibrosus and protrusion of the nucleus pulposus, which compresses the nerve roots, spinal cord and other tissues, and causes lumbar and leg pain and lower extremity entrapment pain and other symptoms. It can be induced by sudden twisting and exertion of the lumbar region or prolonged ambulatory writing and carrying heavy objects. Patients with lumbar spine lesions and lumbar disc herniation are advised to seek timely medical attention for a clear diagnosis and targeted treatment under the guidance of a doctor.