Gastrointestinal daytime is fine at night more than 2:00 difficult may be related to improper diet, irritable bowel syndrome, duodenal ulcer and other factors. 1. Improper diet: some patients are busy at work during the day, will simply cope with the diet, to the evening only have time to eat, will intake of too much food, but the night of the gastrointestinal function is relatively weak, can not be as soon as possible to decompose and digest the food, resulting in the emergence of gastrointestinal difficulties. 2. Irritable bowel syndrome: patients will be in the state of sympathetic excitation during the day, so there is no particularly obvious symptoms, but at night, the parasympathetic nerves will be relatively excited, the ability to control the intestinal tract will be gradually reduced, so in the evening there will be abdominal distension, which can be accompanied by diarrhea, abdominal pain and other symptoms. 3. Duodenal ulcer: If the patient has a duodenal ulcer, the secretion of gastric acid at night can directly stimulate the fasting state of the ulcer, because there is no food in the stomach to dilute the gastric acid, which will cause stimulation of the mucous membrane, resulting in abdominal pain and other uncomfortable symptoms. In addition, there are many other causes of gastrointestinal daytime normal, difficult at night, if the symptoms are serious, or continue to see no improvement, it is recommended to go to the regular hospital in a timely manner, clear cause, under the guidance of the doctor for targeted treatment.