High carboxyhemoglobin is often the result of carbon monoxide poisoning and requires medical attention.
Carbon monoxide and hemoglobin can form carboxyhemoglobin, carbon monoxide and hemoglobin affinity is 210 times that of oxygen, when carbon monoxide and hemoglobin molecules in a hemoglobin combination of hemoglobin will increase the affinity of the remaining three hemoglobin to oxygen, so that hemoglobin binding oxygen is not easy to release, the body is in a state of hypoxia.
At the same time, carbon monoxide can also inhibit glycolysis in red blood cells, reducing energy production in red blood cells, further aggravating tissue hypoxia.
In patients with carbon monoxide poisoning, when carboxyhemoglobin reaches 50%, the skin mucosa will appear cherry red.