The application of tacrolimus ointment for lupus erythematosus can relieve the symptoms of skin erythema to a certain extent, but the actual efficacy of the treatment is related to the patient’s individual physical condition, the specific type of the disease, and the severity of the disease. Lupus erythematosus is divided into systemic lupus erythematosus and cutaneous lupus erythematosus, of which cutaneous lupus erythematosus is also divided into acute cutaneous lupus erythematosus, subacute cutaneous lupus erythematosus, chronic cutaneous lupus erythematosus, etc. Tacrolimus Ointment can inhibit the activation of T-lymphocytes and thus play a role in immunomodulation or immunosuppression. Tacrolimus ointment can play a certain therapeutic role in the skin erythema of lupus erythematosus patients, but the specific efficacy of the patient according to the individual constitution, the specific type of the disease, the difference in the condition of the different existence of different patients, the use of patients with the common adverse drug reactions include burning sensation of the skin, itching, allergic reactions and influenza-like symptoms, and so on. It is forbidden to use in people who are allergic to the components of the drug. Note that the drug should not be used for a long time and continuously. Avoid use in potentially worsening skin diseases and malignant skin diseases. It should not be used in immunocompromised adults and children. Prior to treatment, infected foci of the treated area should be removed. The drug should be used under the supervision of a physician, and it is recommended that patients with lupus erythematosus who need to use tacrolimus go to the Department of Rheumatology and Immunology of a regular hospital for consultation.