Dry, flaky and itchy skin around the mouth can be caused by physiological factors, such as dry skin, or by pathologic factors, such as seborrheic dermatitis, contact dermatitis and other factors. It is recommended that the patient under the guidance of a doctor to clarify the specific cause of the symptoms of the treatment. 1. Dry skin: when the patient is in a dry environment for a long time, it may lead to dryness around the lips, and even peeling and itching. At this time, patients should do a good job of moisturizing the lips, if necessary, can be used to urea vitamin E cream. 2. seborrheic dermatitis: for seborrheic dermatitis caused by dry lips peeling itchy, you can take oral B vitamins, external application of calcium-modulating phosphatase inhibitor drugs such as tacrolimus treatment. 3. Contact dermatitis: For patients with contact dermatitis, avoid re-exposure to sensitizing substances, which can be improved by calcium-modulated phosphatase inhibitor drugs, such as tacrolimus and pimecrolimus. In the case of severe itching, oral antihistamines, such as levocetirizine hydrochloride, olopatadine hydrochloride, etc. can be taken. For patients with dry and itchy skin around the mouth, it is recommended to go to a regular hospital in time, under the guidance of a professional doctor for standardized treatment.