Urethral infection is very painful may be the infection is more serious or combined with urethral stone, combined with urethral malignant tumor and other reasons. 1. serious infection: urethral infection may be related to poor hygiene or unclean sex, when the infection is more serious, may lead to local damage to the urethra, will cause obvious pain, may also be accompanied by urinary frequency and urgency and other symptoms, and may even appear naked eye hematuria. 2. Combined with urethral stones: when there are urethral stones, the pain is usually more obvious, accompanied by urinary difficulties, urinary frequency, hematuria and other symptoms. 3. Combined with malignant tumor of urethra: when combined with malignant tumor of urethra, pain can also occur, and may also be due to the tumor pressure on the urethra and other factors leading to the emergence of urinary difficulties, urinary retention and other symptoms, and tumor rupture and bleeding may also appear in the naked eye hematuria and other symptoms. When the situation of painful urinary tract infection occurs, it is recommended to consult a doctor for examination, to clarify the specific causes and timely treatment.