Prolonged use of povidone-iodine on the same area may lead to side effects such as hyperpigmentation or disruption of normal flora. 1. Hyperpigmentation: Using high concentration of povidone iodine or using povidone iodine in the same area for a long time may lead to hyperpigmentation of the skin, which usually improves gradually after stopping the use. 2. Destruction of normal flora: long-term use of povidone-iodine not only disinfects the contaminated or infected area, but also destroys the surrounding normal tissues and normal flora, which can easily lead to local metabolic disorders or the production of fungi. It is recommended that patients with infected wounds should seek medical attention for debridement, or take oral antibiotics under the direction of a doctor to eliminate the infection. Avoid using iodophor in large quantities for a long period of time without a doctor’s instruction.