Raltitrexed is a chemotherapeutic drug, which is mainly used for the treatment of advanced colorectal cancer and breast cancer and other malignant tumors. The common side effects after the application of raltitrexed are as follows: a. Gastrointestinal adverse reactions, which are mainly manifested as decreased appetite, nausea, vomiting and diarrhea. Bone marrow suppression can also occur after the application of Raltitrexed, which is mainly manifested as the reduction of neutrophils. Liver function damage, some applications of raltitrexed will appear after the reversible glutathione, glutamic oxalacetic transaminase elevation. Mucositis, some patients may develop mucositis, mainly oral mucosal ulcers, after the application of Raltitrexed. Systemic symptoms, some patients may experience fatigue, skin pigmentation and other systemic symptoms after the application of Raltitrexed.