High γ-glutamyltransferase may be caused by physiological factors, but also may be caused by liver disease, pancreatic disease and other disease factors. Normal people’s serum γ-glutamyltransferase is mainly from the liver, if there is hyper-synthesis in the liver or bile discharge is blocked, the serum γ-glutamyltransferase will be elevated; its elevation can be seen in the consumption of alcohol, strenuous exercise, and often stay up late and other physiological conditions. In addition, viral hepatitis, alcoholic hepatitis, cirrhosis and other liver diseases, sclerosing cholangitis and other biliary tract obstruction diseases, as well as pancreatic diseases such as pancreatitis, pancreatic cancer and other pancreatic diseases can cause γ-glutamyltransferase elevation. It is recommended to go to the hospital after excluding physiological factors in the case of high gamma-glutamyltransferase.