Gout can strike at the knee. Gout is a metabolic disease caused by purine metabolism disorders, acute gout is most common in the hock, toe, ankle, knee, wrist, elbow and small joints of the hands and feet, manifested as redness, swelling and pain, which may be accompanied by fever, malaise, etc., the attack occurs at night, and decreases in the daytime, and the attack stops after a few days to a few weeks. Therefore, gout can attack at the knee. When gout occurs in the knee, medications such as non-steroidal anti-inflammatory drugs (NSAIDs) such as Loxoprofen sodium, colchicine, and glucocorticosteroids such as prednisone can be used aggressively to relieve the symptoms of swollen and painful joints. Gout non-exacerbation can be actively used such as benzbromarone, febuxostat and other uric acid-lowering treatment. If gout involves the knee, go to the rheumatology and immunology department of the regular hospital as soon as possible, and follow the doctor’s instructions to standardize the use of medication.