The lack of menstruation after stopping hormone replacement therapy may be related to age factor and ovarian hypoplasia. 1. Age factor: for older women, in the perimenopausal period, itself will have menstrual disorders, so this time to cooperate with the doctor to give hormone replacement therapy, may be after stopping the drug is still unable to normal menstruation, mainly related to the decline in hormone levels. 2. Ovarian hypoplasia: For young women, if there is no menstruation after stopping hormone replacement therapy, it needs to be highly suspected that it is related to ovarian hypoplasia, such as premature ovarian failure, chromosomal abnormalities, autoimmune diseases, medical injury and other factors, which may result in damage to the ovarian tissue, and then ovarian function decline. It is recommended that women should go to the hospital as soon as possible after the occurrence of the above situation, so that a professional physician can carry out the relevant diagnosis and determine the cause before treatment.