Most cystic occupations in the tail of the pancreas are benign, but there is a possibility of malignancy. There are benign and malignant tumors of cystic occupations in the tail of the pancreas, and the need for relevant treatment should be decided according to the size and nature of the cystic occupations in the pancreas, comorbidities, and the patient’s physical condition. If the cystic occupancy is less than 1cm, malignant tumor is not considered for the time being, and there are no complications or serious symptoms, it is recommended to do ultrasound or MRI of the pancreas in about 3-6 months for regular observation. If the cystic mass is larger than 1-2cm, it is recommended to further improve the magnetic resonance imaging to roughly clarify the nature of the cystic mass. Ultrasound gastroscopy can also be done to puncture the pancreatic cyst and pathologic examination can be done to determine the cause of the cystic occupation. Whether benign or malignant, cystic occupations in the tail of the pancreas should be taken seriously after the discovery of a tumor in the tail of the pancreas or pancreas. It is recommended to actively improve the relevant examinations under the guidance of the doctor to help determine the nature of the tumor, which may require surgical treatment if necessary. Once it develops into malignant tumor, it is highly malignant, prone to local infiltration and metastasis, and has poor prognosis, so it must be diagnosed and treated according to the doctor’s instructions and regular review.