The best way to take folic acid is between meals, for example, after lunch and before dinner, usually between 3 and 5 pm, when it is best bioavailable and can be best utilized, absorbed and digested. However, for a kind of people, with the exception of patients with impaired gastric function or previous gastrectomy, upper gastrointestinal bleeding, liver and kidney insufficiency, etc., it is usually not recommended to take it on an empty stomach, and it is best to take it 30 minutes after lunch or dinner for best results. In addition, for patients with very good gastrointestinal function, it can also be taken between 1-2 hours after breakfast, when the gastrointestinal tract is basically emptied and the absorption of folic acid is relatively good.