Vitiligo is a common acquired pigment loss skin and mucous membrane disease that can involve hair follicles and clinically manifest as white patches or (and) white hair. Vitiligo of the vulva can be treated with topical glucocorticoids, topical calcium-modulated phosphatase inhibitors, and topical vitamin D3 derivatives. 1. topical glucocorticoids: glucocorticoids such as dianabed cream can be applied to the white spots, the progression of the efficacy of the better. It is necessary to pay attention to the adverse reactions such as skin atrophy and capillary dilatation caused by long-term local application. 2. Topical calcium-modulated phosphatase inhibitors: Tacrolimus ointment can be applied to the face, mucous membranes and tender areas. Adverse reactions: burning sensation and itching of the skin. 3. Topical vitamin D3 derivatives: e.g. capotriol ointment, can inhibit skin cell proliferation and induce their differentiation. Adverse reactions: reactions at the site of application, such as pruritus, skin irritation and burning sensation. If vulvovaginal vitiligo occurs, please go to the hospital in time, standardized treatment under the guidance of the doctor, do not use drugs without authorization.