Non-invasive generally refers to non-invasive DNA prenatal testing technology, mainly used for the examination of fetal chromosomes, applicable to pregnant women with common chromosomal abnormalities in the fetus, it is worth noting that interventional prenatal diagnosis and patients with malignant tumors and other patients prohibit this test. Non-invasive DNA prenatal testing technology is currently used to detect fetal chromosomal abnormalities, mainly to detect whether the fetus suffers from three major chromosomal diseases. Non-invasive DNA prenatal testing technology is mainly applicable to pregnant women whose fetus’s risk of common chromosome aneuploidy has a risk value between the high-risk cut value and 1/1000 at the time of serum screening. It should be noted that pregnant women with diagnoses such as preeclampsia, fever, and bleeding tendency at the time of interventional prenatal are generally not eligible for noninvasive DNA prenatal testing. In addition, pregnant women with malignant tumors cannot have non-invasive i.e. non-invasive DNA prenatal testing. Non-invasive in addition to non-invasive DNA prenatal testing techniques also include non-invasive surgery, which refers to surgical techniques that minimize the degree of damage. Patients should choose specific non-invasive tests as well as non-invasive treatments based on their specific condition.