Adverse reactions such as pain at the vaccination site, fever, drowsiness, loss of appetite, anaphylactic shock, etc. may occur with the 13-valent Pneumonia Vaccine. The probability of redness, swelling and pain at the vaccination site after vaccination is high, and the probability of serious adverse reactions such as anaphylactic shock is extremely low. Thirteen-valent pneumonia vaccine, also known as thirteen-valent pneumococcal polysaccharide conjugate vaccine, can prevent pneumonia caused by a variety of pneumococcal infections after vaccination. The chance of adverse reactions after receiving the 13-valent Pneumococcal Vaccine is related to the individual’s physical condition. Some people do not have any adverse reactions after vaccination. Redness, swelling and pain at the vaccination site are more likely to occur after vaccination, but they usually recover on their own. Clinical manifestations such as mild fever, loss of appetite, weakness and drowsiness may also occur after vaccination with 13-valent Pneumococcal Vaccine (PVPV), which are more common and usually recoverable on their own. The probability of anaphylaxis after vaccination is extremely low.