The greater intermarine is located on the palm of the hand, if there is pressure pain here, there are often the following causes: 1, trauma: if the patient due to acute trauma caused by soft tissue edema, pain, or even hand fracture, the greater intermarine can appear obvious pressure pain symptoms. The local blood circulation can be improved by appropriate hot compresses and massage. Pain due to soft tissue trauma can also be reduced by applying topical fotarine ointment. For the case with fracture, need to improve the X examination, emergency surgery internal fixation, so that the local tissue pain symptoms gradually improve; 2, chronic strain and aseptic inflammation: can also appear the pain symptoms of the big fish interval, such as long working people, often force will make the local muscles in a long time strain condition, local chronic injury, causing intractable pain. Patients are advised to take proper rest and apply topical drugs to improve local chronic pain; 3. Rheumatoid arthritis, gout: can cause chronic pain between the big fish, need to improve the relevant blood tests, such as rheumatoid factor, uric acid and other indicators. After finding the cause of the disease, active symptomatic and causal treatment can achieve better results.