In adults with weakness and palpitations, two causes should be considered. The first one is non-cardiogenic. First, we should consider whether there are endocrine diseases, such as hyperthyroidism, hypothyroidism, diabetes mellitus, other metabolic diseases and low potassium. Long-term chronic diarrhea and water-electrolyte disorders can cause weakness and palpitations. The second aspect to consider is cardiogenic, if repeated palpitations, chest tightness, chest pain and general weakness. We should consider whether there are arrhythmias and organic diseases of the heart, including coronary heart disease, heart failure, hypertension, hypertensive heart disease and other corresponding diseases. Therefore, once the weakness and palpitations occur, go to the hospital and follow the doctor’s advice to monitor blood pressure, blood sugar, electrocardiogram, cardiac ultrasound and thyroid function before clarifying.