There is no such thing as “which is better, Reglanat or Gliclazide”, both are hypoglycemic drugs with their own mechanism of action, contraindications, adverse reactions, etc. It is recommended to follow the doctor’s instructions for use of the drug. Gliclazide is a sulfonylurea hypoglycemic drug that can selectively act on pancreatic islet B cells to promote insulin secretion, and can be used to treat type 2 diabetes. Gliclazide is contraindicated in patients who are allergic to the drug, under treatment with miconazole, leukopenia, and type 1 diabetes. Adverse reactions of Glipizide include hypoglycemia, nausea, vomiting, urticaria, leukopenia. Repaglinide can promote the release of insulin from the pancreas, which in turn plays a role in lowering blood glucose, and can also be used to treat type 2 diabetes mellitus that cannot be effectively controlled by dietary control and exercise; it is contraindicated in those who are allergic to the drug, type 1 diabetes mellitus, and those who have severe abnormalities in liver function. Adverse effects of Repaglinide include hypoglycemia, metrorrhagia, abdominal pain, diarrhea, and liver dysfunction. Patients who need to use Rigolenide or Gliclazide for treatment should take it under the guidance of a doctor.