Waking up in the morning to find knee pain and swelling may be due to knee synovitis, rheumatoid arthritis, local osteophytes and other causes, it is recommended that patients should be based on the cause of the disease, conservative treatment, and under the guidance of the doctor to take medication or surgical treatment. 1. Knee synovitis: Patients suffering from knee synovitis should first avoid walking for a long period of time, and can promote blood circulation through hot compresses and physical therapy under the guidance of the doctor to alleviate the patient’s discomfort, or take anti-inflammatory and pain-relieving medications as prescribed by the doctor, such as diclofenac sodium delayed-release tablets, loxoprofen sodium tablets and so on. 2. Rheumatoid arthritis: patients with rheumatoid arthritis can take non-steroidal anti-inflammatory drugs as prescribed by the doctor, such as meloxicam tablets, naproxen tablets, etc. Patients with bone damage or deformity of the joints, but also go to the hospital in a timely manner to carry out surgery, such as artificial joint replacement surgery, arthroscopic subluxation surgery. 3. Localized osteomalacia: patients with localized osteomalacia can do sports in moderation, avoiding strenuous exercise, and can take nutritional cartilage drugs under the guidance of doctors, such as glucosamine sulfate tablets, glucosamine hydrochloride tablets, and so on. It is recommended that patients should pay attention to keep warm during the recovery period, maintain a good state of mind, if the situation is more serious, should also go to the hospital in time.