Small blisters on the hands of 4-year-old children, most of them are symptoms of chickenpox, ringworm, impetigo or hand, foot and mouth disease. 1. Chickenpox is caused by viral infection, spread through the respiratory tract, has a strong contagious, winter and spring are common. The manifestation of the cycle of scattered blisters, blisters around a red halo, after a period of time, blisters can be self-broken crust, the course of the disease about two weeks or so. 2. Ringworm is caused by fungal infection, transmitted through skin contact. Blister ringworm can be manifested as intensive subcutaneous blisters appearing on the skin of the hands, and the blisters can dry up on their own to form desquamation, with obvious itching. 3. impetigo is caused by bacterial infection, and the child’s body immunity is low. The main manifestation of the skin appeared on a bean to coin size blisters, blisters within the yellowish liquid, easy to rupture, rupture after the liquid outflow, can be infected to other parts of the body. 4. Hand, foot and mouth disease is a skin disease caused by enterovirus infection, mainly manifested as scattered blisters and papules on the hands, feet, perioral and oral cavity, often accompanied by elevated body temperature, diarrhea, cough and other symptoms. 4-year-old children with small blisters on the hands, there may be other reasons, it is recommended to go to the hospital in time to improve the examination to clarify the cause of the disease, under the guidance of the doctor to give targeted treatment or treatment.