Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease. Although there is no cure so far, with active and standardized treatment, the disease can be effectively controlled, and most patients can achieve complete remission and can study, work and live as normal people. In addition, female SLE patients with well-controlled disease can also get married and have children. Compared with the past, the prognosis of SLE has been significantly improved, with 5-year survival rate reaching 90% and 10-year survival rate reaching 85%. SLE is a highly heterogeneous disease, and clinicians will develop specific treatment plans for patients according to the severity of the disease and the risk-benefit ratio of treatment. General treatment: bed rest is recommended for patients in the acute stage, and those with stable conditions should be appropriately active, avoid excessive sun exposure, use UV protection, avoid overexertion, and also actively treat symptoms and remove various factors that affect the prognosis of the disease, such as paying attention to controlling hypertension, preventing and controlling various infections, and actively treating complications. Treatment of mild SLE: For mild SlE, although there is lupus activity, but the symptoms are mild, only manifesting as photosensitivity, rash, arthritis or mild plasma membrane inflammation without obvious visceral damage, the therapeutic drugs include: ① Non-steroidal anti-inflammatory drugs (NSAIDs) such as diclofenac, meloxicam, etc., which can be used to control arthritis, as well as pain in muscles and joints. ②Anti-malarials can control rash and reduce photosensitivity, commonly used hydroxychloroquine 0.2-0.4g/d. ③Small doses of hormones (e.g. prednisone 5-7.5mg/d) can be added. ④ Consider using immunosuppressants such as azathioprine, methotrexate or cyclophosphamide when necessary on balance. It should be noted that mild SLE can be aggravated by allergy, infection, pregnancy and childbirth, environmental changes and other factors, and even enter lupus crisis. Treatment of severe SLE: There are two main stages, namely induction of remission and maintenance therapy. Induction remission aims to rapidly control the disease, stop or reverse visceral damage, and strive for complete remission of the disease (including recovery of symptoms, function of damaged organs and indicators of disease activity). Currently, most patients need more than six months to one year to achieve remission during the induction remission period. Commonly used drugs include: ① Glucocorticoid: It is the basic drug for the treatment of SLE, and the usual dosage is 0.5-1mg/(kg・d). In the case of SLE with important organ involvement or even lupus crisis, higher doses (≥2mg/(kg・d)) or even methylprednisolone shock therapy can be used. Cyclophosphamide: It is one of the effective drugs for the treatment of severe SLE, especially in patients with lupus nephritis and combined vasculitis. The combination of cyclophosphamide and hormone therapy can effectively induce disease remission, stop and reverse the development of lesions, and improve the long-term prognosis. (iii) Azathioprine: less effective than cyclophosphamide shock therapy in controlling renal and neurological lesions, but better for pluritis, hematologic system, and rash. ④Methotrexate: mainly used for SLE with arthritis, pluritis and skin damage as the main cause, with better tolerability for long-term use. The dose is 7.5~15mg, once a week. ⑤ Cyclosporine A: It is a non-cytotoxic immunosuppressant. In the treatment of SLE, it is effective for lupus nephritis and can be used at a dose of 3-5mg/(kg・d) of cyclosporine A, divided into two oral doses. Mycophenolate: Mycophenolate is effective in the treatment of lupus nephritis at a dose of 10-30mg/(kg.d) in 2 oral doses. after SLE achieves induction remission, consolidation therapy should be continued. The aim is to prevent relapse of the disease with the least amount of drugs and to maintain the patient in a “disease-free state” as much as possible. Usually oral prednisone 7.5-10 mg/d and oral azathioprine 50-100 mg/d are used to maintain the disease, and some patients need hormone therapy for life. Do not be deterred by the side effects on the drug instructions and then discontinue the drug on your own, causing the disease to continue to progress and losing the best time for treatment, which is regrettable. It must be emphasized that patients should follow medical advice, cooperate with treatment, follow up regularly, and never stop the medication without authorization. The side effects are not terrible, what is terrible is the irregular medication, which is the key to successful treatment. New methods of SLE treatment: ① Targeted biologics: There are many biologics related to SLE entering experimental research and clinical trials. Targeted therapies for B cells include: anti-CD20 monoclonal antibody (Rituximab), anti-CD22 monoclonal antibody (epratuzumab), anti-BLyS (B lymphocyte stimulator) antibody, B cell tolerogen (LJP-934); targeted therapies for T cells: CTLA-4Ig has entered phase II/III clinical trials with good preliminary results and few side effects . In recent years, due to the rapid development of research on immune regulatory pathways, targeted therapy has become a new milestone in the treatment of SLE. With the rise of biologically targeted therapy, the treatment strategy for SLE has entered a new era, and we should have more confidence in overcoming this persistent disease in the near future. ②Hematopoietic stem cell transplantation (HSCT): Preliminary studies have shown that HSCT is effective in treating SLE. Due to the risk and possibility of recurrence, HSCT should not be used as a routine treatment for SLE, but it is a possible treatment option for some patients with refractory SLE. ③Immunosorbent: A large number of clinical observations abroad have proved the efficacy of immunosorbent in the treatment of refractory SLE patients. For patients with LN, critically ill SLE, or those with poor results of hormone plus immunosuppression, plasma exchange or immunosorbent therapy can be considered. Immunosorbent combined with immunosuppressive therapy is the only way to achieve long-term results, but it should not be abused. Finally, remind the majority of patients and friends, suffering from rheumatic diseases must go to the regular hospital rheumatology and immunology, do not believe in rumors, the so-called “ancestral secret recipes, special drugs” and other false propaganda, in the end you are not only cheated out of money, but also the loss of health, such lessons are very painful, and often seen; and then do not The Chinese medicine has no side effects, Chinese medicine treats the root cause, Western medicine treats the symptoms, and give up Western medicine treatment, resulting in the disease is difficult to control or stable and then relapse. In fact, “medicine is three parts poison”, Chinese medicine also has side effects, and some are very serious, long-term use of Chinese medicine led to liver and kidney function damage is not uncommon in clinical cases; then again, Western medicine is both the symptoms and the root cause of treatment, symptomatic treatment in SLE is the treatment of symptoms, regulation of immune therapy is the root cause, although the clinical performance of SLE is varied, but the immune dysfunction is a variety. Although the clinical manifestations of SLE are various, but the immune dysfunction is the root of its pathogenesis; at the same time, Western medicine is concerned with individualized treatment, that is, the doctor according to the different disease conditions of each patient to develop different treatment plans, so we often see that although suffering from the same disease, but the treatment plan in different people is not exactly the same. In conclusion, the treatment of SLE should always adhere to the principle of Western medicine as the mainstay, and the treatment should be carried out actively and systematically in order to achieve the ideal treatment effect.