Lupus erythematosus: it is a common disease that brings problems to many patients. How to detect SLE at an early stage plays a rather important role in the treatment of SLE. Since the early manifestation of SLE is often atypical. Sometimes, only one symptom, sign or experimental abnormality is the main basis, which often cannot be confirmed or misdiagnosed as other diseases. Thus, it cannot be treated early and correctly, resulting in mis-treatment or deterioration. Then how can early detection of lupus erythematosus patients be achieved, so that they will not be diagnosed and treated only after they have damaged multiple organs and systems? Young women with one or two of the following symptoms should be suspected of having SLE, and follow-up observation and in-depth examination are needed: (1) Recurrent fever of unknown origin for a long time. (2) Muscle pain, weakness, and joint pain without joint deformity and swelling. (3) Enlarged liver, spleen and lymph nodes of unknown origin. (4) Oral and nasal mucosal ulcers of unknown cause. (5) Dryness of the mouth, eyes, and nose of unknown cause. (6) Raynaud’s phenomenon, or other vascular lesions, arteritis, phlebitis. (7) Thrombocytopenia, or (and) leukopenia, or (and) mild anemia. (8) Allergy to multiple drugs or (and) photosensitivity. (9) Cardiac, pulmonary, pleural, or renal lesions without specific pathogens. (10) Unexplained increased clots in blood sedimentation. (11) Sore throat, foreign body sensation in the pharynx. Vomiting and nausea. (12) Facial flushing or erythema or rash. (13) Abnormal liver or kidney function, especially abnormal flocculent reaction, or (and) persistent hyperglobulin of unknown cause, or (and) reduced plasma protein. (14) Abnormal urinalysis