Lupus erythematosus is a disease of the immune system, and patients with low immunity should seek medical treatment as soon as possible after getting a cold to prevent relapse or aggravation of the disease, or even pneumonia or sepsis. Colds can be caused by viral infections such as influenza virus, rhinovirus, adenovirus, etc. Patients can develop upper respiratory symptoms and can therefore be treated with antiviral drugs and immunoglobulins. There are also colds caused by bacterial infections in the upper respiratory tract, which can be treated with antibiotics under the guidance of a doctor. At the same time, we should closely monitor the activity of lupus erythematosus disease, improve blood routine, anti-double-stranded DNA antibody and other examinations, pay attention to whether fresh rashes and ulcers appear on the skin of the whole body, and if the patient’s disease progresses, active treatment with hormones and immunosuppressive drugs is needed. Patients with lupus erythematosus should pay attention to warmth and sun protection after catching a cold. Try to choose high-calorie, high-protein and vitamin-rich food for diet. Avoid overexertion, ensure sufficient sleep, and try not to go to crowded, confined and dirty air environment. Most of the patients with lupus erythematosus need long-term drug treatment, and exertion or random discontinuation of drugs will lead to relapse or aggravation of the disease, so you should review regularly and adjust the medication.