Lupus erythematosus is a rheumatic immune disease that affects young women. The disease can be mild or severe. In mild cases, it may affect only the skin and joints, while in severe cases, it can affect many organs throughout the body and even affect life. To enable early diagnosis, further autoantibodies such as ANA, anti-dsDNA and anti-Sm antibodies are needed to clarify the diagnosis for unexplained fever, malaise, hair loss, weight loss, anemia, rash after sun exposure, arthralgia, arthritis, kidney lesions, pleurisy, recurrent miscarriage and epilepsy.