In patients with darkness around the mouth, the first thing that needs to be done is to check the liver function to see if the patient has elevated ghrelin and ghrelin transaminases as well as elevated bilirubin. This is most often seen in patients who have a combination of hepatitis, either viral hepatitis or other hepatitis such as autoimmune hepatitis, alcoholic hepatitis, or drug-induced hepatitis. In this case, the patient needs to look for the cause of the hepatitis, and further treatment should be based on the cause of the hepatitis. If the patient has viral hepatitis, it is necessary to further investigate the type of hepatitis and whether the patient has viral replication. If there is viral replication, combined with liver function impairment, we should actively consider antiviral treatment. Secondly, for some patients, due to the lack of trace elements, as well as the patient’s night rest is not good, may also appear in the patient’s darkness around the mouth. For this kind of situation, patients should pay attention to timely rest, do not stay up late, do not labor. In addition, pay attention to rest at night, moderate oral intake of a variety of trace elements, patients will slowly get better.