Intestinal lipofuscinosis, also known as mesenteric lipofuscinosis, clinically belongs to the category of lipofuscinosis, which is an extensive thickening of the mesentery caused by a nonspecific inflammatory process, and extensive fibrosis of the mesentery later in the course of the disease is called regressive mesenteritis. The names used to describe this disease are also mesenteric fatty hypertrophy, mesenteric lipid granuloma, isolated mesenteric lipodystrophy, etc. Its symptoms and treatment are as follows: 1. Symptoms: mainly seen in middle-aged and elderly people, clinical manifestations are not specific, patients often show recurrent episodes of spasmodic abdominal pain, abdominal pain can be limited or diffuse, mostly located on the right side of the waist, patients are often accompanied by weight loss, nausea, vomiting and Some patients may also unintentionally find abdominal masses with local tenderness during physical examination or abdominal dissection, but usually without signs of peritoneal irritation. A few patients may also have a large amount of ascites formation, and these main symptoms are due to necrosis of the mesenteric adipose tissue, causing fibrosis; 2. Treatment: The disease is self-limiting and has a good prognosis. Usually within 2 years, the pain disappears and the masses recede in most patients. For the treatment of mesenteric lipofuscinosis, the main thing is symptomatic treatment, including the use of some antispasmodic and analgesic drugs such as ibuprofen when the pain is obvious, anti-infective drugs and immunosuppressive therapy such as cephalosporin, penicillin, glucocorticoids and cyclosporine when digestive symptoms appear, and patients with significant abdominal pain and abdominal masses, or when the abdominal masses are large compressing the intestinal cavity, surgery can be chosen Excisional treatment. The pathogenesis of mesenteric lipofuscinosis is related to the body’s immune deficiency, trauma to the mesenteric adipose tissue, subacute infection, taking drugs for ischemic lesions, or adverse factors such as allergies. When mesenteric lipofuscinosis is suspected, it is recommended to go to the hospital in a timely manner and undergo relevant examinations, such as X-ray and abdominal CT, to clarify the cause and then actively remove the causative factors to slow down the development of the disease and prevent complications.