The common causes of unusually large hard pimples on the face such as boils, sebaceous cysts, and acne are treated to address the cause. This usually includes general treatment, medication, surgery and other methods. 1. Boils: are caused by bacterial infections of human hair follicles or sebaceous glands, and are prone to form red swellings with recurring characteristics, and can be treated with medications applied locally, such as 2% mupirocin ointment, compound polymyxin B ointment, and so on. If abscess formation, can also be surgical incision drainage. 2. Sebaceous cysts: because of sebaceous gland duct obstruction caused by sebaceous gland excretion obstruction, resulting in sebum and other stagnant formation of cystic swelling, can be used under local anesthesia surgical excision treatment. 3. Acne: a chronic inflammatory skin disease, with abnormal hormone levels, excessive sebum secretion, bacterial infections, hyperkeratosis of epithelial cells, etc., can be local topical medication, such as retinoic acid cream, tazarotene gel, etc., but also oral antibiotics, such as minocycline, doxycycline and so on. The face long particularly large hard acne, it is recommended to pay attention to timely go to the hospital to do the relevant examination, you can choose the appropriate treatment for the situation, not blindly use their own medication. Drugs need to be used in accordance with medical advice.