The first thing to rule out is the presence of rheumatoid arthritis. Rheumatoid arthritis often causes pain in joints throughout the body. In the early stages of rheumatoid arthritis, it often involves the small joints of the body, such as the finger joints, ankles, and wrists. In the later stages, pain in the knee and hip joints is present. Patients may not only exhibit pain in joints throughout the body, but also significant morning stiffness and limited movement. The pain is often especially pronounced when it is cloudy, rainy, or when the temperature drops, and in severe cases, deformities of the joints may occur. In this case, you can consider the four rheumatic tests to rule out the possibility of rheumatoid arthritis. Secondly, some middle-aged and elderly people or menopausal women often have osteoporosis because of severe calcium loss. Osteoporosis involves the thoracic and lumbar segments of the body in the early stages, manifesting as pain in the back and lumbar region. In the later stages, if the osteoporosis is very severe, this will manifest as generalized weakness and pain in the bones of the body. Zoledronic acid can be considered for the treatment of the generalized pain caused by osteoporosis. For this kind of osteoporosis, X-ray examination and bone density examination are required.