Acute gastroenteritis can use amoxicillin for anti-infective treatment, but need to pay attention to avoid contraindications, the emergence of adverse reactions to stop the drug in time. Amoxicillin has good antibacterial ability against bacterial infections such as Escherichia coli and staphylococcus. It can be used for the treatment of acute gastroenteritis caused by Escherichia coli, staphylococcus and other sensitive bacteria. However, it should be noted that it is recommended to clarify the strain of infection before treatment with the drug, and if the symptoms are not relieved by the use of amoxicillin treatment, it is recommended to adjust the drug according to the drug sensitivity test. In the course of oral amoxicillin treatment, if rash, fever, asthma, anemia and other serious adverse reactions, it is recommended to stop using the drug and consult a doctor. For drug allergy, infectious mononucleosis and other prohibited use, with asthma, hay fever, lactation during pregnancy to use the drug with caution. The occurrence of acute gastroenteritis timely to the hospital; the above drugs need to be used under the guidance of clinicians.