Urinary creatinine of more than 40,000 μmol/L may be due to physiological reasons such as strenuous exercise, pathological reasons such as diabetic nephropathy, etc. The normal value of urinary creatinine is 7,000~18,000 μmol/L for men and 5,300~16,000 μmol/L for women. Physiological causes include increased muscle metabolism leading to increased urinary creatinine, such as strenuous exercise, eating a large amount of meat or protein will cause an increase in urinary creatinine. In this case, no special treatment is needed, and the creatinine will return to normal after it is metabolized from the body. Pathological causes include diabetic nephropathy, nephrotic syndrome, glomerulonephritis, etc. Most of the creatinine is excreted by the kidneys, and damage to the kidneys can cause an increase in the glomerular filtration rate, and an increase in the creatinine excretion, so the urinary creatinine will be elevated accordingly. Patients are advised to find out the cause of elevated creatinine in time and treat the cause. Patients with elevated urinary creatinine are advised to go to the hospital in time and under the guidance of the doctor for standardized diagnosis and treatment.