Difficulty in sleeping when hungry is generally a normal physiological phenomenon that can be relieved by eating; however, the presence of digestive system diseases can aggravate this symptom performance and requires timely diagnosis at a hospital and medication. In general, it is difficult to fall asleep because there is no stomach content to neutralize stomach acid, thus stimulating the gastric mucosa; at the same time, when the blood glucose concentration is low, the whole body will feel uncomfortable, which makes it difficult to fall asleep. At this time, it is recommended to supplement food. If you are only hungry with almost no other discomfort, you can eat easily digestible noodles and porridge; if you are extremely hungry and have low blood sugar, you can eat some fruits or drink a glass of honey water to replenish enough glucose in a shorter period of time. It should be noted that it is important to avoid eating too much food before going to bed, because heavy gastrointestinal burden and digestion difficulties can also affect sleep. In addition, hunger for sleep may also be caused by duodenal ulcer, which can often lead to evening hunger pains, usually relieved after eating and aggravated at night, on an empty stomach, and can be alleviated by taking acid suppressants, such as omeprazole. It is recommended to go to the hospital the next day for a detailed examination, such as gastroscopy, to confirm the diagnosis of peptic ulcer, and to treat it promptly after diagnosis, taking drugs to inhibit gastric acid secretion as well as gastric mucosal protective agents such as Rebapate and Thioglycollate under the guidance of the doctor to avoid the progression of the ulcer and the risk of causing perforation of the digestive tract and bleeding. Paying attention to maintaining good eating habits in daily life, eating on time, three meals a day and a balanced diet can effectively reduce the probability of developing digestive system diseases.