Dapoxetine hydrochloride in advance how long to take no accurate answer, it is related to the patient’s personal situation, according to the instructions of the drug prompted, can be taken 1 to 3 hours in advance, but the specific time in advance also need to depend on the patient’s own situation. Dapoxetine hydrochloride is used for male patients aged 18 to 64 years old with premature ejaculation; it can also be used for male patients aged 18 to 64 years old with poor ejaculation control, and its main mechanism is to inhibit the ejaculation drive reflex, so that the ejaculation time is prolonged, so as to achieve the therapeutic purpose. The drug can be taken before or after meals, there is basically no effect on the absorption of the drug, and alcohol should not be consumed when using the drug. The drug and strong cytochrome P450 3A4 inhibitors such as itraconazole, ketoconazole, ritonavir and other drugs in combination, will make its own blood concentration increased. It also has drug interactions with thioridazine and monoamine oxidase inhibitors. Adverse reactions such as nausea, diarrhea, headache, insomnia, dizziness and even fainting may occur after use. Contraindicated in the following cases: use of strong cytochrome P450 3A4 inhibitors; use of thioridazine or within 14 days of discontinuation of the drug; use of monoamine oxidase inhibitors or within 14 days of discontinuation of the drug; severe renal and hepatic insufficiency; moderate hepatic insufficiency; heart failure NYHA class II-IV and other significant cardiac pathology; allergy to the drug. Use with caution in the following conditions: taking moderate cytochrome P450 3A4 inhibitors such as clarithromycin; mild to moderate renal insufficiency. If you need to use the drug, please strictly follow the instructions of the doctor under the guidance of the medication, do not use the drug arbitrarily.