High blood creatinine may be caused by a variety of factors, mainly physiological and pathological reasons. 1. Physiological: blood creatinine may increase after strenuous exercise or consuming a large amount of meat, and usually return to normal after removing related factors. 2. Pathologic: including acute and chronic renal failure. Acute renal failure is divided into pre-renal, renal and post-renal. Chronic renal failure is the final outcome of the continuous progress of various chronic kidney diseases, and the treatment is mainly aimed at slowing down the progress of renal function and preventing the deterioration of renal function. Patients with high blood creatinine should go to the hospital in time for consultation, clarification of the cause of the disease under the guidance of professional physicians and timely treatment.