Newborns spitting up all the time may be caused by physiological factors or by diseases, such as infection, intestinal obstruction, intestinal atresia and so on. 1. Physiological reasons: the newborn’s stomach is horizontal, the stomach capacity is small, the cardia sphincter is not well developed, the pyloric function has been developed, so it is easy to spit up the phenomenon. Newborns have poor gastrointestinal neuromodulation, insufficient secretion of gastric acid and digestive enzymes, and low ability of the central nervous system to control vomiting, which can easily lead to spitting up when breastfeeding is overdone or in an incorrect position. 2. Pathological factors: gastrointestinal disorders, respiratory or digestive tract infections, intracranial infections and their genetic metabolic disorders, can all lead to spitting up. Congenital esophageal tracheal fistula, gastric torsion, intestinal obstruction, necrotizing small bowel colitis in newborns, biliary atresia and congenital pyloric hypertrophy and other diseases can also lead to spitting up. To sum up, there are many reasons that cause newborns to spit up, once a newborn often spits up, must go to the local pediatric clinic in time, clear the cause of the disease as soon as possible after treatment.