First, 15% of hypertensive patients will directly turn into uremic syndrome. China’s 1998 statistics, hypertension patients accounted for 10% of the total population, that is, every 10 people have 1 hypertensive patients, of which 1.5 people will become uremic patients. Second, 30% of diabetic patients, direct conversion is uremic diabetes. Recent statistics show that in our population, there are 43.2 million people with diabetes and 50.64 million people with reduced glucose tolerance, the sum of the two is 93.84 million. In other words, only because of diabetes China has about 13 million uremic patients and more than 15 million people at risk of uremia. Third, kidney disease is the main cause of uremia, and the final outcome of all chronic kidney diseases will be uremia. This is where chronic nephritis is the primary cause, and chronic glomerulonephritis accounts for 55.7% of the diseases that lead to uremia. Fourth, urinary tract infection or urinary tract infection caused. According to statistics, the incidence of urinary tract infections in China is 0.23% for men and 2.37% for women. Men and women of all ages can develop, especially married women of childbearing age is common, in China, chronic pyelonephritis is the second factor of uremia, accounting for 21.2%. Fifth, drugs caused by varying degrees of toxic side effects. Studies have shown that about 25% of patients with renal failure are associated with the nephrotoxicity of drugs. Sixth, related to age. As we age, the structure and function of the kidneys undergo significant degenerative changes. Under normal circumstances, the human kidney has a strong compensatory function, when the kidney function is lost 50%, it can still maintain the normal life activities of the human body, for example, after the removal of a kidney, the person can still survive in good health. As we age, the storage function of human body gradually decreases or even loses, without additional burden, kidney function can meet the needs of human life activities, but there is no ability to cope with sudden injury and disease. Seven, uremia caused by HIV infection is on the rise. This cause now accounts for 1% of the causative factors of uremia.