Indications for breast cancer susceptibility gene testing

  The test can be used to understand the risk of breast cancer in people who do not have obvious symptoms but have the following risk factors, and provide them with primary prevention measures. These risk factors include: age: the incidence rate is higher between 40 and 45 years old, and continues to rise after menopause, reaching a peak around 70 years old; postmenopausal estrogen supplementation; early menarche, late menopause, infertility, and advanced first birth; family history; lobular hyperplasia or atypical hyperplasia; overnutrition, obesity, high-calorie, high-fat diet; thyroid disease and endocrine disorders, immune function Decreased immune function; infertility, few births, late age of first full-term birth, early age of menarche; ionizing radiation; oral contraceptive pills; alcohol consumption, smoking; self-inflicted ovarian disease; mental stress, infrequent exercise, etc.  The test can be used to understand the risk of breast cancer when there are small, painless, solitary lumps, localized breast elevation and skin depression, flattened, retracted or sunken nipples, dermal edema and “orange peel-like” skin changes.  Because of the similarity of symptoms, endometrial cancer needs to be differentiated from fibroadenoma, which is one of the following diseases. However, fibroadenoma should not be easily diagnosed in women after 40 years of age and malignancy must be excluded. Cystic hyperplasia of the breast with lumps or localized breast thickening that is not clearly demarcated from the surrounding breast tissue. Therefore, for patients who cannot be diagnosed or have suspicion, this test can be used to understand the risk of breast cancer in the subject and finally decide whether a biopsy should be used to confirm the diagnosis.  If the test result is “–” or “-“, it is recommended that although this test determines that you are at low risk, if you are exposed to more adverse lifestyle, nutritional and environmental factors, it may increase your risk of developing the disease. Please consult with our medical experts.  The genetic loci we have tested indicate that you are at low or no risk of developing the disease, but this does not mean that you will not develop the disease, as there is a certain incidence in the general population, so you should not neglect your health concerns. Breast cancer is one of the common malignant tumors in women, and the incidence rate in China is about 56.2 per 100,000.  Enhanced surveillance: A: Monthly breast self-examinations since the age of 25 B: Professional breast check-ups at the hospital at least every 2-3 years since the age of 25-35 C: Annual mammograms since the age of 40 Drug prevention: Drug prevention can be carried out along with enhanced surveillance. Triamcinolone acetonide (tamoxifen), a selective estrogen receptor antagonist, has been shown to reduce the risk of the disease by half. Please follow your doctor’s instructions for its use.  If the test result is “+” or “++” or “++++”, it may be recommended to: intensify monitoring: A: monthly breast self-examinations from the age of 25 years B: from the age of 25-35 years Professional breast examination at least every 2-3 years C: Annual mammogram from age 40 onwards Pharmacological prevention: Pharmacological prevention is available along with enhanced monitoring. Triamcinolone acetonide (tamoxifen), a selective estrogen receptor antagonist, has been shown to reduce the risk of the disease by half. Please follow your doctor’s instructions for specific use. Prophylactic mastectomy: This measure has been shown to reduce the risk of the disease by 90% in women with a BRCA gene variant. However, this is a very important measure and should be considered with caution and medical advice.