1.Palpable lumps or lumps that do not go away in the breast, skin, tongue or any part of the body. 2.Changes in warts or moles on the body, such as deepening of color, enlargement, itching, ulcers and other conditions persistent indigestion. 3.Choking sensation and pain when swallowing food, sternal stuffiness and discomfort, foreign body feeling in the esophagus. 4.Unusual heavy bleeding during menstruation, irregular vaginal bleeding outside the menstrual period or after menopause. 5.Persistent hoarseness, dry cough or blood in sputum. 6.Unexplained blood and mucus in the stool or alternating diarrhea and constipation or unexplained hematuria. 7.The appearance of long-standing wounds or ulcers on the body. 8.Unexplained weight loss over a long period of time. 9.Tinnitus, hearing loss, nasal congestion, headache, and blood in nasopharyngeal secretions from aspiration and coughing.