Esophageal thickening may be caused by various reasons, such as esophagitis, esophageal Crohn’s disease, esophageal smooth muscle tumor or lipoma, esophageal cancer, etc. The main treatment is to treat the primary disease, such as medication, surgery, etc., and if necessary, consider radiotherapy and esophageal stent placement. 1. Esophagitis: If the thickening of esophagus is caused by bacterial or fungal esophagitis, drug treatment should be carried out under the guidance of professional doctors, and the drugs for anti-bacterial infections include amoxicillin or cephalosporin, etc., and the drugs for anti-fungal infections include fluconazole or mycobacteria. 2. Esophageal Crohn’s disease: For the thickening of esophagus caused by this disease, glucocorticoids and immunosuppressants can be applied under the guidance of doctors, such as prednisolone, salazosulfapyridine, etc., to control the inflammation. 3. Esophageal smooth muscle tumor or lipoma: it can be treated by surgical resection with the diagnosis and treatment advice of professional doctors, and timely repair to make the esophageal wall return to normal. 4. Esophageal cancer: If esophageal cancer causes thickening of esophagus, the patient should cooperate with doctor for surgical treatment as soon as possible. If esophageal cancer is in advanced stage and surgery is impossible, radiotherapy can be considered, and esophageal stent can be implanted if necessary to ensure normal feeding. If esophageal thickening occurs, it is recommended to go to regular hospitals for consultation and examination as soon as possible, so as to clarify the cause of the disease and adopt targeted treatment plan to control the condition in time.