Children coughing at night around 12 o’clock, need to consider the upper respiratory tract infection, cough variant asthma, environmental factors. 1. Upper respiratory tract infection: this is a common cause of children coughing at night, mostly due to viral infections caused by nasal and pharyngeal secretions backflow stimulation of the pharynx after the infection causes coughing. 2. Cough variant asthma: there is airway hyperresponsiveness, mostly occurring at night or early in the morning, mainly irritating dry cough, duration >1 month, diagnostic use of bronchodilators, antihistamines, symptomatic relief to help confirm the diagnosis. 3. Environmental factors: If the indoor air quality is poor at night, the indoor environment is cold, may also be a common cause of coughing, pay attention to maintain indoor ventilation, appropriate temperature and humidity. Children coughing at night around 12 o’clock may also have other reasons, it is recommended to go to the hospital in a timely manner, improve the examination to clarify the cause of the disease, give targeted treatment or treatment.