Segmental ventricular wall motion abnormalities on echocardiography are due to myocardial ischemia and hypoxia with reduced myocardial activity, myocardial remodeling, and fibrosis. Most of the time, similar conditions occur due to severe previous myocardial ischemia, such as acute myocardial infarction and ischemic cardiomyopathy. After similar findings on the echocardiogram, it is recommended to complete an electrocardiogram, coronary CTA or coronary angiography to clarify the presence and severity of coronary artery disease. If necessary, blood flow reconstruction, such as coronary intervention or coronary artery bypass grafting, should be performed. Some patients with previous myocarditis or other types of cardiomyopathy may also show segmental ventricular wall motion abnormalities on echocardiography, requiring a differential diagnosis by a cardiologist in a clinical setting.