Ankylosing spondylitis may be passed on to children, but it is impossible to generalize. Ankylosing spondylitis is a chronic inflammatory disease with lesions in the sacroiliac joints, spine and peripheral joints, which may be accompanied by extra-articular manifestations of varying degrees in the eyes, lungs, cardiovascular system and intestinal tract. The cause of ankylosing spondylitis is not yet clear, but it has a certain degree of family aggregation. If a patient’s first-degree relative suffers from ankylosing spondylitis, the probability of his/her being affected by the disease is relatively higher than that of his/her peers, but due to the differences in individuals, it is impossible to make a generalization. Ankylosing spondylitis can also be caused by infections, immunocompromise, and other factors. Patients may experience pain and discomfort in the lower back, sacroiliac area, buttocks, groin, etc. It may also be accompanied by the symptom of lumbar stiffness, which may worsen in the morning or during sedentary rising, and may be alleviated after activities. It is recommended that patients with ankylosing spondylitis take relevant treatment measures in time to avoid delaying the condition. At the same time, for patients who want to have children, genetic counseling is available.