The treatment of lupus is based on anti-inflammatory and immunosuppression, and commonly used drugs include prednisone, hydroxychloroquine, and merti-macrolide. Lupus generally refers to systemic lupus erythematosus (SLE), discoid lupus erythematosus (DLE), and so on, which can be localized skin damage; in addition to the skin, it can also involve the whole body and multiple systems. The treatment of lupus needs to be considered according to the organs involved and the activity of the disease. 1. In lupus with only skin lesions, hydroxychloroquine, thalidomide, or low-dose glucocorticoids such as prednisone may be considered. 2. If lupus manifests as joint swelling and pain, plasma membrane inflammation, without obvious organ damage, small-dose glucocorticosteroids such as prednisone, methotrexate, hydroxychloroquine, etc. may be considered. 3. Lupus involves the kidney, heart, lung, nerves and other organs, in addition to medium and large dose glucocorticosteroids such as methylprednisolone, it is necessary to actively combine with immunosuppressant drugs such as cyclophosphamide, merti-macrolide, etc. If necessary, use biologic drugs such as beclomethasone. If necessary, biological agents such as belimumab and tetracycline should be used. If you have lupus, you should go to the rheumatology and immunology department of the hospital in time to seek a standardized diagnosis and treatment plan to control the disease in time.