The pain may be caused by the following reasons: 1. the stimulation of the drug itself, when the vaginal mucosa is inflamed, congestion and edema are more serious, the use of the gel will lead to local irritation and cause pain, most of the pain symptoms will be reduced as soon as possible after continuing to use the drug. 2. the use of the gel has led to the breakage of the local mucosa. If the mucous membrane is inflamed, edema is relatively serious, congestion is also more serious, with solid things to stimulate the local may lead to mucous membrane breakage, will cause local pain, often bloody discharge, it is recommended to stop using the drug, go to the hospital to check where caused by the breakage, and then give the appropriate treatment.