Pain in the bones of the patient’s legs is commonly caused by epiphysitis, osteoporosis, and fatigue osteochondritis of the calf, as follows: First, epiphysitis: If the pain is in the front of the calf for adolescents, it is usually caused by tibial epiphysitis of the knee joint, which is related to strenuous exercise and acute trauma, and the patient will show pain and limited movement of the knee joint. Second, osteoporosis: If the bone pain occurs for elderly patients, it is usually caused by osteoporosis, and the patient will show pain in the bones of the lower limbs, weakness in walking, or even sudden leg muscle cramps during sleep at night, making the pain symptoms worse. Third, calf fatigue osteochondritis: prolonged strenuous exercise can cause calf tibia fatigue osteochondritis, which can manifest as calf bone pain, and in severe cases, fatigue fractures can occur. Therefore, leg bone pain should be diagnosed early and clarify the cause, according to the cause to choose the appropriate treatment.