A patchy abnormal signal shadow in the spleen with slightly low T1 and T2 signals suggests that there may be nodules in the spleen, which is often related to infection, lymphoma, splenic hemangioma and other factors. 1. Infection: mainly including bacterial infection, tuberculosis infection and parasitic infection, nodular shadow will be formed after repeated stimulation of spleen by disease-causing bacteria, and the examination will show a patchy abnormal signal shadow with weak T1 and T2 signals. 2. Lymphoma: it may be primary lymphoma, or it may be the tumor formed after the metastasis of tumor from other parts to the lymph nodes in the spleen. When the tumor is enlarged, magnetic resonance examination will show flaky abnormal signal shadow, and the T1 and T2 signals are relatively low. 3. Hepatosplenic hemangioma: It is a benign tumor that occurs in the liver and spleen tissues, and when calcification is formed, it will be detected as a flaky signal shadow. If there are flaky signal shadows in the spleen with low T1 and T2 signals, it is recommended to carry out the next diagnosis through enhanced CT, pathological biopsy and puncture examination, and carry out regular treatment under the guidance of doctors in combination with the cause of the disease.