The causes of high serum creatine kinase include acute myocardial infarction, myocarditis, post-thrombolytic therapy for myocardial infarction, muscle disease and surgery. 1. Acute myocardial infarction: creatine kinase can be significantly elevated in 3~8 hours after the onset of the disease, and reach the peak value in 10~36 hours, and return to normal in 3~4 days. 2. Myocarditis: myocarditis damages the myocardium, and creatine kinase can be significantly elevated. 3. After thrombolysis of myocardial infarction: reperfusion occurs after thrombolysis of myocardial infarction, resulting in myocardial ischemia and reperfusion injury, leading to creatine kinase elevation again. 4. Muscle diseases: such as polymyositis, rhabdomyolysis, etc., the lesion damage to the muscle leads to the elevation of creatine kinase. 5. Surgery: Both cardiac surgery and non-cardiac surgery can lead to elevated creatine kinase, and the degree of increase is related to the degree of muscle damage, the scope of surgery, and the duration of surgery. If you find elevated creatine kinase, you should go to the hospital and ask your doctor for diagnosis and treatment.