Simvastatin and Atorvastatin cannot be compared to see which is better, it depends on which is more suitable for the patient. Simvastatin belongs to the more traditional lipid-lowering drugs, mainly used in the treatment of hypercholesterolemia, and needs to be taken at night. Adverse reactions such as nausea and diarrhea may occur after use. Patients with active liver disease should not use this drug. Atorvastatin belongs to a new generation of lipid-lowering drugs, which can be used for the treatment of hypercholesterolemia, and adverse reactions such as liver enzyme abnormalities and pain in the limbs may occur after use. Pregnant and lactating women should not use the drug. Simvastatin and atorvastatin have certain differences in efficacy, but there is no good or bad, both can be used for the treatment of hyperlipidemia, different patients have different responses to the drug, to choose a more appropriate drug for the patient. Clinically, when choosing statin lipid-lowering drugs, it is necessary to refer to the patient’s physical condition, drug allergy history, affordability and other factors, and use the drug under the guidance of the physician.