The development of this disease may be related to the following factors: Obesity An increase in body weight is directly related to the development of osteoarthritis of the knee. Obesity is also an aggravating factor. Weight loss in obese individuals may reduce the incidence of osteoarthritis of the knee. Bone density When the subchondral trabeculae become thin and stiff, they are less tolerant to stress and are therefore more likely to develop osteoarthritis in people with osteoporosis. Trauma and force tolerance Abnormal conditions of the joint, such as when the link is in an unstable state after patellar resection, can lead to degenerative changes in the cartilage when the joint is subjected to muscle imbalance and local stress. Normal joints and activities or even after strenuous exercise will not develop osteoarthritis. Genetic factors The involvement of joints varies from race to race, for example, osteoarthritis of the hip and carpometacarpal joints is more common in Caucasians, but less common in people of color and nationalities, and gender also has an effect, with the disease being more common in women. Data show that the incidence of osteoarthritis in mothers and sisters of women with Heberden’s nodes is 2-3 times higher than in family members without the disease.